ORGN 275 |
| R. Jeremy Woods, Justin O. Brower, Chris M. Gothard, Mehrnoosh Hashemzadeh, Omid Khakshoor, Wade A. Russu, and James S. Nowick. Department of Chemistry, University of California, Irvine, Irvine, CA 92697-2025 |
| In spite of recent advances, the creation of small β-sheet peptides that fold into well-defined structures in aqueous solution remains challenging. This paper presents a unique class of peptides that adopt robust, well-defined β-sheet structures in aqueous solution. The peptides are 42-membered ring cyclic decamers containing the unnatural amino acid β-sheet template Hao [JACS 2000, 122, 7654] and two δ-ornithine turn units [JACS 2003, 125, 876]. These macrocyclic β-sheets are readily linked to form multivalent structures and can be viewed as modules for the design of macromolecular and supramolecular structures. |
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Proteins, Peptides, Amino Acids, and Nucleotides
1:00 PM-5:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- 303D, Oral
Division of Organic Chemistry |
