ORGN 371 |
Dynamics of capsular host-guest exchange using fluorescence resonance energy transfer
| Shannon M. Biros1, Liam C. Palmer1, Shirley Lin2, and Julius Rebek Jr.1. (1) The Skaggs Institute for Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., MB 26, La Jolla, CA 92037, (2) Department of Chemistry, U.S. Naval Academy, 572 Holloway Rd, Annapolis, MD 21402 |
The dimeric assembly shown below is capable of encapsulating a wide variety of guests, and these complexes have been well studied using 1D and 2D NMR techniques. These studies have provided a picture of the kinetically stable host-guest complex, while the details of exchange are more elusive. Exchange is thought to occur via one of two mechanisms, depending on the size of included guest. Fluorescence spectroscopy permits investigation of assembly processes that are difficult to measure by NMR. Host monomers bearing complimentary fluorescent dyes have been synthesized and used to study the energetics of exchange.  |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Sci-Mix
Division of Organic Chemistry
The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004
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