Solid-phase total synthesis of scytalidamide A

ORGN 449

Wenxin Gu and R. B. Silverman. Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208
Scytalidamide A, a cyclic heptapeptide that was recently isolated from a cultured marine fungus of the Genus Scytalidium, was shown to have selective anticancer activity toward CACA-2 colon carcinoma. The first solid-phase total synthesis of scytalidamide A was achieved using two different linker resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin.

 

Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster

Division of Organic Chemistry

The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004