ORGN 134 |
| David M. Hodgson and Shuji Hachisu. Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, United Kingdom |
| Addition of alkyl radicals to 2-sulfonyl-7-tert-butoxycarbonyl-7-azabicyclo[2.2.1] heptadiene 1 led to the formation of 2-azabicycles 2 via tandem intermolecular radical addition – homoallylic radical rearrangement. This new methodology has been applied to the concise total syntheses of α-isokainic acid 3 and a known biologically active kainoid analogue 4. Efforts are underway to carry out the total synthesis of α-kainic acid 5. |
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |
