Solid-phase synthesis of asymmetric stilbenes

ORGN 328

Kwangyong Park and Chul-Hee Cho. Department of Chemical Engineering, Chung-Ang University, Huksuk-Dong 221, Dongjak-Ku, Seoul, 156-756, South Korea
The nickel-catalyzed cross-coupling reactions of polymer-bound stilbenesulfonates with various arylmagnesium bromides produce asymmetric stilbene derivatives in good yields. Polymer-bound stilbenesulfonates are prepared by the consecutive Suzuki-Miyaura reaction and Horner-Wadsworth-Emmons reaction of polymer-bound bromobenzenesulfonates.

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