ORGN 273 |
| Xiaogang Qu, Lab 5, Lab 5, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, 5625 Renmin Street, Changchun, Jilin, China, 130022, China |
| There are several principal components that combine to stabilize DNA-drug interactions, which include the following: drug structure (size and stereochemistry); solution conditions and DNA sequence dependent conformation and deformability. Ligands with high binding affinity and strong selectivity have potentially useful genomic based therapeutic and diagnostic applications. Thus, understanding how both the drug and the DNA contribute to the overall stabilizing (and destabilizing) forces in complex formation is fundamental to the full characterization of drug interactions. Our studies clearly show that the binding of 7-amino ACTD to its core sequence in seven DNA oligomers is strongly affected by differences in length and context of the flanking sequence, and enthalpy-entropy compensation is accompanying the favorable interaction between ligand and DNA. The author thanks Dr. J. B. Chaires and Dr. A. S. Benight for all the supports. |
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Proteins, Peptides, Amino Acids, and Nucleotides
1:00 PM-5:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- 303D, Oral
Division of Organic Chemistry |