ORGN 518 |
| Jeffrey Marrero, Abimael D. Rodríguez, Peter Baran, and Raphael Raptis. Department of Chemistry, University of Puerto Rico, PO Box 23346, San Juan, PR 00931-3346 |
| Bielschowskysin (1) is a naturally occurring regular diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure possesses several unusual stuctural features. In addition to having two cyclic hemiacetals, a g -lactone, and a tetrasubstituted cyclobutane moeities, bielschowskysin (1) is based on a previously undescribed tricyclo[9.3.0.02,10]tetradecane ring system whose structure was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin (1) was shown to exhibit strong antimalarial activity against Plasmodium falciparum. |
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Total Synthesis, Asymmetric Reactions and Syntheses, Bioorganic
9:00 AM-11:00 AM, Wednesday, March 31, 2004 Anaheim Convention Center -- Hall C, Poster
Sci-Mix
Division of Organic Chemistry |