ORGN 357 |
| Byeong Hyo Kim, Hun Pyo Hong, Kui Tae Cho, Jeung Hoon On, In Seok Jeong, Geun Sig Cha, Young Moo Jun, and Hakhyun Nam. Department of Chemistry, Kwangwoon University, 447-1 Nowon-ku Wolgye-dong, Seoul, 139-701, South Korea |
| The concept of molecular tweezer-type neutral carriers based on a cholic acid backbone (CAB) has been successfully utilized by us to yield highly selective ionophores for carbonate, calcium, copper and silver. The CAB-based carriers may be as versatile as calix[n]arenes for developing selective ionophores. Based on our initial success in several CAB-based neutral carriers, we design new silver ion-selective ionophores with the same frame. Six tweezer-type and six non-tweezer-type ionophores containing dithiocarbamoyl groups on a 7-deoxycholic amide or cholane derivative were designed and synthesized. Potentiometric evaluation of the PVC membranes containing those deoxycholic amides/cholanes bearing tweezer-type dithiocarbamoyl moieties with a short linkage showed excellent affinity and selectivity to silver(I) ion over alkali, alkaline earth and other transition metal cations. However, deoxycholic amides/cholanes substituted with one dithiocarbamoyl group, i.e. non-tweezer-type ionophores result in relatively poor potentiometric responses. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |