ORGN 344 |
Parallel solution-phase synthesis of tetra-substituted purines
| Xu Bai, Qun Dang, Jianxin Yang, Jinglin Liu, Zhonglin Wei, Hengbin Zhang, and Jinchang Wu. Center for Combinatorial Chemistry and Drug Discovery, Jilin University, 75 Jinlai St., Changchun, Jilin 130012, China |
Purine ring containing compounds are important structural units in bio-molecules showing wide-range of pharmacological activities. They have been studied extensively in the literature. However, few synthetic methods were reported for fully substituted purine analog so far. This report presented a convenient preparation of tetra-substituted purines in solution phase as shown in the following scheme starting from a series of 2-substituted 5-amino-4,6-dichloropyrimidines. Mono-substitution by an amine followed by cyclization to form the purine ring and a final amine substitution yielded tetra-substituted purine libraries. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Hall A, Sci-Mix
Division of Organic Chemistry
The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004
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