ORGN 140 |
Efficient synthesis of 3-substituted pyrimidinones
| Jae Uk Jeong, Xiaohong Chen, Attiq Rahman, Dennis S. Yamashita, and Juan I. Luengo. Medicinal Chemistry, GlaxoSmithKline Pharm, 1250 South Collegeville Road, Collegeville, PA 19426 |
| Many biologically active compounds such as PPAR agonists and angiotensin antagonists contain 3-substituted pyrimidinones. A novel and efficient synthesis of 3-substituted pyrimidinones has been developed. The key step involves the cyclization of enamides, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines. The general procedure, scope and application of this synthetic method will be discussed.  |
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry
The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004
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