ORGN 550 |
| Brittany L. Hayes and Michael J. Collins Jr. Life Sciences Division, CEM Corporation, 3100 Smith Farm Road, Matthews, NC 28106 |
| The use of microwave irradiation in organic synthesis has gained widespread acceptance and use within the pharmaceutical arena. It has become a new enabling technology for drug discovery and development. Libraries for lead generation and optimization can be accomplished in a fraction of the time over conventional methods. Innovative technology for automating these chemistries has been developed. One interesting heterocyclic reaction is the Ugi Four Component Condensation (U4CC). It is a versatile one-pot reaction, which combines an amine, an aldehyde, a carboxylic acid, and an isocyanide to yield an alpha-acylamino amide. By attaching a solid phase resin to one of the amino groups in the diaminoarene compound, which acts like a protecting group, we can force a cyclodehydration reaction upon cleavage of the resin to yield nitrogen-containing heterocycles. Herein, we will demonstrate the utility of microwave irradiation in solid phase heterocyclic library synthesis and the technology that has been designed to automate these applications. |
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Combinatorial, parallel, and solid-phase chemistry
1:00 PM-5:00 PM, Wednesday, March 31, 2004 Anaheim Convention Center -- 303A, Oral
Division of Organic Chemistry |
