ORGN 138 |
| Elisa Leyva, Alicia Sagredo, Angeles Cabrero, Denisse A. de Loera, and Socorro Leyva. Department of Chemistry, Universidad Autonoma de San Luis Potosi, San Luis Potosi, 78210, Mexico |
| We report an easy and general method for the synthesis of 1-ethyl-7-(4-acetyl-1-piperazinyl)-6-fluoroquinolone-3-carboxilic acid. For comparision, several 7-halogen or piperazinyl-6-fluoroquinolone-3-carboxilic acids were prepared. These 7-substituted derivatives were compared for antiinfective activity using minimum inhibitory concentrations against a variety of bacteria. The introduction of the acetyl group in the structure of the piperazinyl improved significantly Gram-negative and Gram-positive activity for the piperazinylquinolones. The intermediate compounds and final products were characterized by H' NMR spectral data. This analytical technique was particularly useful to monitor the reactions through the synthesis. |
|
New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |