ORGN 151 |
| Julius Rebek Jr., The Skaggs Institute for Chemical Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, MB26, La Jolla, CA 92037 |
| Encapsulation complexes are molecular hosts that completely surround their guests. In these, host superstructures self-assemble in the presence of suitable guests. They are held together by weak intermolecular forces such as hydrogen bonds and they operate at thermodynamic equilibrium, ambient temperatures and in the liquid phase. Encapsulation is governed by the fit of the guest in the host, a form of molecular recognition. Larger capsules can surround two or more molecules and even several different molecules can be coencapsulated. These assemblies exist on timescales of milliseconds to hours, long enough for many types of interactions and even reactions to take place within them. The complex of 8 benzene molecules inside a hexameric resorcinarene capsule is shown below. |
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Ronald Breslow Award for Achievement in Biomimetic Chemistry
9:25 AM-12:00 PM, Monday, March 29, 2004 Anaheim Convention Center -- Bllrm A/B, Oral
Division of Organic Chemistry |
