ORGN 347 |
| Qunjie Wang, Agilent Technologies Inc, 2850 Centerville Road, Wilmington, DE 19808 |
| Because of the large difference in property for each individual compound within a library, it is sometimes hard to get the whole library purified by HPLC using same gradient profile. We have developed a pH screening method that helps effectively resolve each mixture within a small library in a high throughput fashion. A small pyrazole library of 16 individual mixture has been successfully purified using such a method. A parallel post-treatment may further remove any reagent residue that may interfere in the HTS process of the library to ensure high quality and avoid false results. |
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Physical Organic, Combinatorial, Materials, Molecular Recognition
8:00 PM-10:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |