ORGN 274 |
| Tobin J. Dickerson, Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., BCC-582, La Jolla, CA 92037 and Kim D. Janda, Department of Chemistry and the Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037. |
| Despite a body of evidence supporting the deleterious health risks associated with tobacco use, a vast number of people continue to suffer from smoking-related ailments. In order to fully understand the role of smoking in the onset and advancement of many of its associated disease states, we have recently initiated a research program studying the role of long-lived nicotine metabolites in disease. Specifically, we have studied the role of nornicotine, a metabolite we have shown capable of participating in both the catalysis of the aldol reaction and the aberrant covalent glycation of proteins. This lecture will summarize our recent findings in this area, including the effects of this phenomenon in scenarios such as the aggregation of the amyloid ß-protein. |
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Proteins, Peptides, Amino Acids, and Nucleotides
1:00 PM-5:00 PM, Tuesday, March 30, 2004 Anaheim Convention Center -- 303D, Oral
Division of Organic Chemistry |