Information-based library approaches

ORGN 388

Jonathan A. Ellman, Department of Chemistry, Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720-1460
Although many different approaches have been proposed for the design of small molecule libraries, information-based library design has proven to be the most effective means for rapidly identifying small molecule ligands to biological targets. Information-based library design can be based upon the structure or mechanism of the biological target or upon previously identified natural or synthetic ligands. Here several productive information-based library approaches will be overviewed.