ORGN 559 |
| Qunjie Wang, Agilent Technologies, 2850 Centerville Road, Wilmington, DE 19808 |
| To get a valid SAR in drug discovery, high purity is required for focused libraries in the bio-screening process. On the other hand, the output of the library purification is also highly demanded in drug discovery research. To address the above issues, we have developed some tools and solutions, especially for the purification of the libraries of drug-like basic compounds, to improve both the quality and output. Some stationary materials and additives in the mobile phase we used may help the separation in the respects of retention, selectivity and loadability. Some convenient post-LC treatment procedures will help in getting pure compounds in free-base form or in the form of desired salts, such as chlorides. |
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Combinatorial, parallel, and solid-phase chemistry
1:00 PM-5:00 PM, Wednesday, March 31, 2004 Anaheim Convention Center -- 303A, Oral
Division of Organic Chemistry |