ORGN 551 |
| Yong Gao, Department of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, Southern Illinois University, Mailcode 4409, Carbondale, IL 62901-4409 |
| Soluble supports have recently received a great deal of research attention as new classes of scaffolds for hosting reagents, catalysts and scavengers. Although significant progress has been made recently, soluble supports that are easily automated to enable rapid purification of a large number of compounds simultaneously by simple operations, are still highly called for. Superparamagnetic nanoparticles are a new class of soluble supports for organic and solution-phase combinatorial/organic syntheses. The nanometer-sized core/shell Fe2O3 particles synthesized in our group exhibited high solubility and stability in various organic media. These particles have a superparamagnetic iron oxide core protected with a thin layer of the divinylbenzene (DVB) cross-linked polystyrene polymers that can serve as the linkage point for anchoring the reactive species. The thin (~5 nm) DVB cross-linked polystyrene coatings are robust enough serving as a cage to prevent the aggregation of the iron oxide cores, and yet thin enough (with a molecular weight of 8 K) to allow these particles to exhibit high solubility in organic media. In this talk, we would like to discuss our synthesis of the nanoparticular supports and the use of such matrixes for the solution-phase organic reactions. In particular, we will discuss the peptide-elongation reactions and Diels-Alder reactions. |
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Combinatorial, parallel, and solid-phase chemistry
1:00 PM-5:00 PM, Wednesday, March 31, 2004 Anaheim Convention Center -- 303A, Oral
Division of Organic Chemistry |