ORGN 87 |
| George Y. Li, CombiPhos Catalysts, Inc, P.O. Box 220, Princeton, NJ 08542-0220 |
| Palladium-catalyzed cross-coupling reactions are widely used approaches to forming a wide variety of carbon-carbon, carbon-nitrogen, carbon-sulfur bonds. However, in many cases, reaction requires different phosphorous ligands or different ratio of Pd/ligand to "fit" with each catalytic cycle, therefore no single catalyst can be applied for all cross-coupling reactions. We successfully found a mixture of air-stable metal-phosphinous acid compounds to be remarkably active and efficient catalysts for almost all cross-coupling reactions of aryl halides with arylboronic acids, olefins, amines, and thiols. Herein, we report a "combinatorial" mixture of air-stable palladium complexes served as efficient catalyst precursors for many C-C, C-N, and C-S bond-forming reactions of aryl halides. |
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |