ORGN 106 |
| G Seelhammer, Department of Chemisty, Department of Chemisty, Concordia College, 537 40th St. S, Moorhead, MN 56560 |
| The necessity of enantiomeric purity in new drug candidates has led recent studies into a method for the preparation of one specific enantiomer in excess of the other. One such effort exists in the utilization of a chiral carbanion bound to lithium, followed by the replacement of the metal through electrophilic substitution. Specifically, these reactions involve the use of nitrogen heterocycles such as pyrrolidine and piperidine as these may some day yield a synthesis of medicinally active pharmacological compounds. An alternate route to the synthesis of amino pyridines through the substitution of a microwave in place of expensive metallic catalysis was also explored. Yields using the techniques we developed for microwave synthesis of amino pyridines have risen from near 10% to an astonishing 90% yield and now show promise for an alternate route to a lithiated intermediate that is crucial for ongoing research into stereo specific synthesis as described above. |
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New Reactions and Methodology, Metal-Mediated Reactions, Heterocycles and Aromatics
8:00 PM-10:00 PM, Sunday, March 28, 2004 Anaheim Convention Center -- Hall A, Poster
Division of Organic Chemistry |