ORGNSunday, September 7, 2003

8:00 PM-10:00 PM Hilton New York -- Rhinelander Center,Poster
Methodology, Process R&D, Combinatorial, Total Synthesis
Organizer:L. McElwee-White
85Activation of kenner's N-Acyl sulfonamide "safety-catch" linker using Pd(0)-catalyzed allylation
Yi He, Laura L. Kiessling
86Applications of organometallic chemistry in the pharmaceutical industry: A mechanistic and kinetic study of the MK-869 hydrogenation network
Thorsten Rosner, Shane Krska, Karel M.J. Brands, Karen M. Conrad, Fuh-Rong Tsay, Fred W. Hartner, Edward G. Corley, Robert A. Reamer, Robert D. Larsen, Mahmoud Kaba, Yongkui Sun
87Asymmetric synthesis of 3-aminohexose glycals: a 7-step synthesis of a protected vancosamine glycal
Wonsuk Chang, Kathlyn A. Parker
88Directional bromination of xylenes
Kaitao Lu, Der-Haw Wang, Peter C. Zhu
89Novel applications of Biginelli reaction. Solution phase parallel synthesis of dihydropyrimidinone, dihydropyrimidinthione, dihydropyrimidothiazine libraries
András Lukács, László Ürge, György Dormán, Ferenc Kálmán, Ferenc Darvas
90Studies toward the total synthesis of Plakevulin A
Katherine L. Hervert, Louis S. Hegedus
91Synthesis of a novel monomer bis(p-hydroxyphenyl)bis(p-chlorophenyl)methane with a tetrahedral configuration
Guodong Dang, Wanjin Zhang, Y. Wei
92Synthesis of macrocyclic a-ketoamides via ring-closing metathesis
John T. Randolph, Peggy Huang, Larry Klein, Dale Kempf
93Total synthesis of molluscan polypropionates using a novel Lewis acid catalyzed cyclization
Aubry Miller, Dirk Trauner
94Towards the total synthesis of the anticancer agent Roseophilin
E.M.E. Viseux, P.J.P. Parsons, J.B.J. Pavey
95Two complementary approaches on 2-alkoxy carboxylic acid synthesis from 1,3-dioxolan-4-ones
Leonard L. Winneroski Jr., Yanping Xu
96Weinreb amide functionalized dipolar species
Richard.W Franck, Ajit Kumar Parhi
97Synthesis of 2,3-disubstituted benzo[b]furans by the palladium-catalyzed coupling of o-iodoanisole and terminal alkynes, followed by electrophilic cyclization
Dawei Yue, Richard C Larock
98Synthesis and reactivity of allenamides and ynamides
Michael R. Tracey, Richard Hsung
99Stereoselective pericyclic reactions involving ynamides
Richard Hsung, Jason A. Mulder, Mike O. Frederick, Michael R. Tracey, Craig A. Zificsak, Robert H. Lambeth III
100Formal [3+3] cycloaddition strategy towards synthesis of highly functionalized piperidines
Nadiya Sydorenko, Richard Hsung, Juliet M. Hahn, Ossama S. Darwish
101Room temperature ionic liquids from a biorenewable resource - D-Fructose
Maurice Okello, Scott T Handy
102Solvent dependent reactions of benzylsulfonylacetic acids
N. Srinivasa Reddy, E. Premkumar Reddy, M.V. Ramana Reddy
103Studies toward an enantioselective total synthesis of tremulenediol A and tremulenolide A: development of a highly regioselective Rh(I)-catalyzed allylic alkylation reaction
Brandon L. Ashfeld, Stephen F. Martin
104Practical route to -ß-alkylated-1,3,2-oxazaborolidines via BH substitution
Margarita Ortiz-Marciales, Eduvigis Gonzalez, Melvin De Jesus, Sandraliz Espinosa, Wildeliz Correa
105Reactions of hydrazine with a-cyanocinnamate esters: an unexpected fragmentation
Paul J. Erdman, David E. Lewis
106Convenient one-pot synthesis of dihydroquinolones
Glen C. Gullickson, David E. Lewis
107One-pot synthesis of N-substituted phthalimides from methylarenes
Saliya de Silva, Saurabh Dhruve, David Isidor, Magambo Nyakirang’ani, Supun Pathirana, Edinam Klu, Tope Osinaiya
108Oxocarbenium ion cyclizations for the synthesis of fumagillin analogues
Fatoumata Camara, Johana Angarita, Galyna Pushchinska, David R. Mootoo
109New reagents for asymmetric electrophilic amination
Alan Armstrong, Ian E. Edmonds, Martin Swarbrick
110New N- and O-arylations with potassium aryltrifluoroborates and cupric acetate
Christopher W. Ajello, Bertrand Le Bourdonnec, Roland E. Dolle
111Highly efficient and chemoselective synthesis of 3, 5-diketoesters by Lipase catalyzed transesterification: application in resolution of racemic alcohols and desymmetrization of meso diols
A. Ian Scott, Samik Nanda
112Highly efficient synthesis of azabicyclo[X.Y.0]alkane amino acids by Rh-catalyzed cyclohydrocarbonylation
Wen-Hua Chiou, Nobuhiro Mizutani, Iwao Ojima
113Isoureas: versatile synthetic intermediates
Bruno Linclau, Stefano Crosignani, Zhengning Li, Patrick Lecarpentier
114Mild and efficient conversion of formamides to isocyanides using the complex of 2,4,6-trichloro[1,3,5]triazine and N,N-dimethyl formamide
Hagyoung Lee, Ki-Jong Han, Misoo Kim
115Diastereoselective synthesis of 2,6-cis-disubstituted tetrahydopyranones: Studies toward the enantioselective preparation of tetrahydropyranone natural products
Christopher A. Lee, Paul E. Floreancig
116Efficient amination of sulfides with a ketomalonate derived oxaziridine
Alan Armstrong, Richard S. Cooke
117Efficient synthesis of 2-alkyl-2-phenoxypropionic acids via a-lactone pathway
Jeremy York, Leonard L. Winneroski Jr., Yanping Xu
118Development of a general strategy for the stereoselective synthesis of highly functionalized carbocycles via an enolate Claisen/diastereoselective ring-closing metathesis protocol
John Robinson, Anthony D. Piscopio
119Development of a novel three component coupling process: Synthesis of substituted pyrimidinones
Dengming Xiao, Eugene Tarlton, Kevin Koch, Anthony D. Piscopio
120CsOH-promoted epoxide ring-opening with phosphines: Mild and efficient synthesis of monohydroxyphosphines
Ashlee A. Robinson, Brandon Frank, Daniel L. Fox, Ralph Nicholas Salvatore
121Convenient procedure for the formylation of amines using formic acid and bis(trichloromethyl) carbonate
Misoo Kim, Ki-Jong Han, Hagyoung Lee
122Desymmetrising aza-wittig reactions
Stephen P Marsden, Jenna Jamal, M. Jonathan Fray
123b-Hydroxy nitriles and 1,3-amino alcohols from epoxides: Improved, one-pot procedures using LiCN in THF
James A. Ciaccio, Michael Smrtka, William Maio
124A new methylenecyclopentane annulation process
H.J. Liu, Liang-Rern Kung, Che-Hao Tu
125A novel route to azobenzenes and its application towards synthesis of dendritic and cyclic polyazobenzenes
Cheon-Gyu Cho, Young-Kwan Lim, Kang-Sang Lee
126Arylchloride-organoboron coupling with bulky imidazolium-palladium carbene catalysts
Merritt B. Andrus, Chun Song, Yudao Ma, Wei Jiang
127A scaleable synthesis of 2,4-disubstituted imidazoles by condensation of amidines and a-haloketones
Z. Bryan Li, Charles K-F Chiu, Richard F. Hank, Jerry Murry, Joshua Roth, Harry Tobiassen
128Group selective intramolecular cycloadditions of sulfenic acids to prochiral alkenes
Patrizia Tisselli, Richard S. Grainger
129Preparation of pivaloyl hydrazide in water
Z. Bryan Li, Raymond J. Bemish, David R. Bill, Steven Brenek, Richard A. Buzon, Charles K-F. Chiu, Lisa Newell
130MgI2 catalyze the aldol-type reaction: a general route to synthesis of (E)-ß-iodovinyl-ß'-hydroxyketones
Han-Xun Wei, Hui Hu, Mohamed A Farag, Paul W. Pare
131Radical-induced cyclopentannulation using nitroaldol(Henry)-derived intermediates
Frederick A. Luzzio, Joel P. Ott
132An improved synthetic route to analogues of the new SERMs WAY-138923 and WAY-140424
Arthur A. Santilli, Marci C. Koko, Andrew Q. Viet
133Synthesis of (S,S)-2-(2-morpholin-2-yl-2-phenyl-methoxy)-phenol
Jaya Prabhakaran, Vattoly J Majo, Theodore S. Wang, J. John Mann, J. S. Dileep Kumar
134Microwave assisted multi-component reactions
Heather Tye, Mark Whittaker, Sarah M Ireland
135Organic reactions in water using hydrophobic polymer-supported Brfnsted acid catalysts
Shinya Iimura, Daisuke Nobutou, Kei Manabe, Shu Kobayashi
136An investigation of the zinc organometallic intermediate in the syn-selective tandem chain extension-aldol reaction of ß-keto esters
Karelle S. Aiken, Charles K. Zercher, Su-jen Lai
137Diastereoselective alkylations of beta-tetrazolyl propionic acids
Michael G. Yang, Dilip P. Modi, Wayne F. Rankin, Jianliang Shi, Ruth R. Wexler, Richard E. Olson
138Dimethyldioxirane mediated rearrangement of bicyclic imidazoles
Yong He, Hongwang Du, Carl J. Lovely
139Side chain incorporation in ketomethylene isosteres
Weimin Lin, Nancy Tryder, Fan Su, Charles K. Zercher
140Regioselectivity in Stille coupling reactions of 3,5-dibromo-2-pyrone
Cheon-Gyu Cho, Won-Suk Kim
141Novel reaction of propargyl alcohols with alkynes promoted by boron trihalides and titanium tetrahalides: synthesis of halogenated 1,4-enynes
George W Kabalka, Zhongzhi Wu, Yuhong Ju
142Practical routes for the synthesis of b,g-unsaturated amino acids
Stephen P Marsden, Paul Alexander, John C. Reader
143Facile synthesis of substituted 2-(amidoalkyl)azoles
Dennis J. Hlasta, Craig A. Zificsak
144A practical synthesis of 2,4-disubstituted resorcinol derivatives
Scott S. Ceglia, Michael H. Kress, James M. McNamara
145Efficient synthesis of 1,4-diaminophthalazines, an important moiety of E8010, a novel PDE type 5 inhibitor
Kazuhiro Yoshizawa, Shinya Abe, Yuki Komatsu, Ken Furukawa, Naoyuki Shimomura
146Intramolecular allylation of erythromycin derivatives
Su Yu, Xiu Wang, Ashok V. Bhatia
147Mechanistic insight into a highly selective preparation of imidazo[1,2-a]pyrimidine
Yun Qian, Michael Breslav, Rosie Chang, Helen Chao, Rong Feng, Steven Goltra, Jeffrey Grimm, Mark Haslego, Aihua Huang, Sergio Cesco-Cancian, Charles Shaw, Cynthia Maryanoff, Mitul Patel, Kirk L. Sorgi, James Weber, Xinzhen(Jane) Xiang, Dawei Xu
148Optimization of a process for the preparation of the farnesyl transferase inhibitor BMS-214662
Zhenrong Guo, Boguslaw M. Mudryk, Zhinong Gao, Terence Moore, Cary McConlogue, David Kronenthal, Melanie Miller, Chien-Kuang Chen
149Stereoselective cyclizations of donor-acceptor cyclopropanes
Brian L. Pagenkopf, Ming Yu
150New linkers for traceless cleavage strategies in solid phase synthesis
Jun Guo, Peter J. H. Scott, Patrick G Steel, Ian B. Campbell
151The development of high-load, soluble reagents via ROMP: Oligomeric sulfoxides and benzyl sulfonates
Mianji Zhang, Joel D. Moore, Daniel L. Flynn, Paul R. Hanson
152Capture-ROMP-release: Applications in synthesis
Shubhasish Mukherjee, Andrew M. Harned, Kevin W. C. Poon, Daniel L. Flynn, Paul R. Hanson
153Novel orthogonal strategy toward solid phase synthesis of 1,3,5-substituted triazines
Jae Wook Lee, Jacqueline T. Bork, Sonya M. Khersonsky, Young-Tae Chang
154Tubuyzine: Novel anti-microtubule compound from triazine-libraries
Daniel P. Walsh, Sonya M. Khersonsky, Young-Tae Chang
155On column clean synthesis of an array of benzofurans using silica-supported reagents cartridges
Shahnaz Ghassemi, P. C. Rahn
156Progress towards a diversity-oriented synthesis of linear polyketides
Daniel E. Macks, James M. Rogér, Derek S. Tan
157Selective catch and release of a synthetically useful phosphine
Jennifer L. Marugg, Martin L. Neitzel, John Tucker
158Novel and efficient method for solution phase parallel synthesis of amides from acid chlorides and amines using PS-HOBT
Nand Baindur, Naresh Chadha, Mark R. Player
159Polymer-supported toluenesulfonic acid: A versatile tool for expedient purification or scavenging of amines and nitrogen heterocycles
Owen W. Gooding, Jeff W. Labadie, Sukanta Bhattacharyya, Tejal Parekh, Lanchi Vo
160Solid phase synthesis of fluorescent Ras-mimetic lipopeptides: Novel cell-permeable substrates of protein palmitoyl acyltransferase
Sangarappan Sivakumar, Steffen P. Creaser, Blake R. Peterson
161Spacer-modified diol-functionalised polystyrene resins: Synthesis and applications
Toby B. Reeve, Sandeep Handa, Philip W.D. Dyer
162Stereoselective diversity-oriented synthesis of spiroketals
Justin S. Potuzak, Sirkka B. Moilanen, Derek S. Tan
163Towards supported olefin-metathesis catalysts
Samuel Suhard, Philip W.D. Dyer
164An efficient capping residual hydroxythiophenol on solid support for synthesis of high quality compound library
Luyong Jiang, Alex Chucholowski, Rongshi Li
165An efficient synthesis of a bicyclic gamma-lactam library on solid support
Tong Zhu, Zheng Yan, Rongshi Li
166Expanded stereochemical diversity in the diversity-oriented synthesis of spiroketals
Sirkka B. Moilanen, Justin S. Potuzak, Derek S. Tan
167Paper Withdrawn
168Development of pseudoephedrine chiral linkers for asymmetric alkylations on solid phase
Panee C. Hutchison, Tom D. Heightman, David J. Procter
169Traceless solid phase synthesis of substituted benzoimidazolones
Wen-Ren Li, Chih-Chung Wang
170Solid-phase oligosaccharide synthesis with real-time reaction monitoring by color test
Shino Manabe, Yukishige Ito
171New Holliday Junction inhibitors and Class B synergimycin derivatives
Irene Medina, Enrique V. Azevedo, Shelli R McAlpine
172Novel Quinopristin antibiotics: Structural derivatives
Chris Carroll, Jennifer L. Robinson, Shelli R McAlpine
173Novel antibiotics: Class B synergimycin derivatives and site specific recombination inhibitors
Maggie J. Shale, Lisa A. Liotta, Megan L Bolla, Shelli R McAlpine
174Synthesis of enantiomerically pure tetrahydrofurans using ylides: Application to the total synthesis of haterumalide NA
Jennifer Schomaker, Pulgam Veera Reddy, Babak Borhan
175Synthetic studies toward (-)-galanthamine. Beckmann rearrangement approach for the seven-membered ring
Keith R. Buszek
176Synthetic studies toward dregeanin. Facile construction of the saturated eight-membered lactone ring
Keith R. Buszek
177Synthetic studies towards Isaindigotidione and its analogues
Ch Yan Poon, Pauline Chiu
178The first enantioselective synthesis of hexahydro TMC-69: A novel method for the construction of 5,6-disubstituted dihydropyran-3-nones
Dengming Xiao, Anthony D. Piscopio
179Total synthesis of azaspiracid. Construction of the CDE ring system
Keith R. Buszek, Tony S. Gibson, Brian C. Reinhardt, Jason R. Sunde
180Total synthesis of the sesquiterpenoid copaene
Sasan Karimi, Julia Christodoulou
181Towards the new diazonamide A: Synthesis of a tyrosine-derived benzofuranone
Francine N Palmer, Christopher J Moody
182Studies towards the total synthesis of FR182877
Frederick W. Goldberg, Alan Armstrong, David Sandham
183Synthesis of (+)-decarestrictine L and the C17-C24 fragment of ambruticin via C-glycosidation
Julie M. Lukesh, William A. Donaldson
184Synthesis of M3 and M1 metabolites of HIV protease inhibitor Nelfinavir Mesylate
Aniruddha P. Patwardhan, Mitali Ghoshal, Jason Klein, Christa Hubner-Parajsz, Josef Endl, Sigrun Metz, Angela Puhlmann, Gerald Sigler, Jane Tsai, Joseph Passarelli
185Synthetic efforts towards Amphidinolide T1
Benjamin R. Travis, Babak Borhan
186Studies toward the total synthesis of bryostatin 1
Gary E. Keck, Anh P. Truong
187Studies toward the total synthesis of halichlorine
Gary E. Keck, Stacey A. Dalton
188Studies toward the total synthesis of swinholide A
Gary E. Keck, Lars Heumann
189Studies toward the total synthesis of epothilone b
Gary E. Keck, Robert L. Giles
190Progress toward the synthesis of Arisugacins and Territrems
Michael E. Jung, Sun-Joon Min
191Progress toward the total synthesis of pseudolaric acids
Zhe Geng, Pauline Chiu
192Paper Withdrawn
193Studies directed toward the total synthesis of gigantecin
Jin She, Michael T. Crimmins
194Exploiting olefin metathesis for the construction of the core of SCH 351448
Michael T. Crimmins, Grace R. Smalley
195Studies toward synthesis of polycyclic polyprenylated acylphloroglucinols
Robert B. Grossman, Roxana Ciochina
196Studies directed towards total synthesis of Rhododaurichromanic acid A
Aleksey V. Kurdyumov, Kristen M. Ihlen, Jiashi Wang, Richard P. Hsung
197Studies directed towards a total synthesis of pinnaic acid
Rameshkumar Chellappan, Richard Hsung
198New approaches to the 13C labelling of (+)-catechin
Neil D. Forrest, Richard C. Hartley, Alan Crozier
199Catalytic asymmetric synthesis of the chiral tetraene acyl side chain of papulacandin D
Huanyan Cao, Kathlyn A. Parker
200Progress on the total synthesis of SNF4435C and D
Yeon-Hee Lim, Kathlyn A. Parker
201Asymmetric total synthesis of C-glycoside of alpha-galactosylceramide
Jun Pu, Richard W. Franck
202Studies towards the total synthesis of the marine alkaloid sarain A
Sungwoo Hong, Steven M. Weinreb
203Total synthesis of C-glycosides of isoflavone
Vishnu Vardhan Reddy Karnati, Wu-Yan Zhang, David Y.W. Lee
204Studies toward the total synthesis of lamellarins
Yanan Zhang, Scott T Handy, Jennifer M Lewis, Jesse J Sabatini
205Synthetic studies of himbacine and its congeners featuring intermolecular Diels-Alder reaction
Masanori Takadoi, Tomoyuki Kawai, Kentaro Yamaguchi, Shiro Terashima
206Utilization of hidden meso-symmetry towards the synthesis of the C22-C36 segment of halichondrin B
Valerie A. Keller, Steven D. Burke
207Total synthesis of a conjugate of a NAALADase inhibitor
Pingyu Ding, Paul Helquist, Marvin J. Miller
208Progress toward the total synthesis of reticulidin A and deoxyreticulidin A
Jacob I. Wasserman, Michael E. Jung
209Synthesis of allylphosphinoyl phenylsulfone: a conjunctive reagent for synthesis of conjugated dienes
Xiaojin Li, Philip L. Fuchs

Symposium Grid -- Division of Organic Chemistry -- Session Listing

The 226th ACS National Meeting, New York, NY, September 7-11, 2003