Synthetic methods towards substituted lactam lactols

ORGN 379

Jonathan Rosen, Todd D. Nelson, Mark A. Huffman, James M. McNamara, Peter G. Dormer, and K. M. J. Brands. Process Research, Merck & Co., Inc, 126 E. Lincoln Ave., RY800-D133P, Rahway, NJ 07065

Synthetic efforts towards the formation of substituted lactam lactols will be presented. The focus will be on two main strategies: 1) Condensation reactions of N-substituted ethanolamines, and 2) reductions of lactam lactones.