ORGN 82 |
| Atul S. Kotnis, Kenneth J. Natalie, Bruce Lotz, Ambarish K. Singh, Raymond E. Weaver, David Kascur, David Thurston, Keming Zhu, and J. Siva Prasad. Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, P. O. Box 191, New Brunswick, NJ 08903-0191 |
| This talk will cover process development issues to prepare aryl boronic acids and use them successfully with iodooxazole in a Pd-mediated Suzuki coupling reaction to assemble the biaryl moiety of an endothelin receptor antagonist. Practical approaches to remove palladium and isolate the penultimate intermediate will be discussed. |
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Process R&D
1:00 PM-5:00 PM, Sunday, September 7, 2003 Sheraton New York -- Royal Ballroom B, Oral
Division of Organic Chemistry |