Synthesis of water-soluble fullerene derivatives and their biological applications

ORGN 425

Li Fan, Kathryn S. Reinhard, and Stephen R. Wilson. Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003
Using the well known Bingel-Hirsch reaction, a series of water-soluble fullerene derivatives have been synthesized. Mono, bis, and tris substituted C60 and C70 compounds with either amino or carboxylic acid side chains were made. Biological properties, such as inhibition of nitric oxide synthase, and water solubility of the derivatives were compared. The synthesis, characterization, and properties will be discussed.

 

Physical Organic, Materials, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Tuesday, September 9, 2003 Hilton New York -- Americas Hall 1, Poster

Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003