ORGN 525 |
| David S. Crumrine, Claudia M. Davila, and Kenneth Olsen. Department of Chemistry, Loyola University Chicago, 6525, N. Sheridan Rd. (flanner hall), Chicago, IL 60626 |
| Photodynamic Therapy (PDT) is a technique that converts light energy into chemical energy that can be used to generate singlet oxygen to destroy tumors. A derivative of Azure B has been prepared and characterized and will now be used to test the theory that combining the dye with a cross-linked hemoglobin could provide an effective tool to kill cancer cells under hypoxic conditions. Different crosslinked hemoglobins may provide different oxygen affinities, which could show different effectiveness in killing hypoxic tumors. The main goal of this research then, is to develop an antibody or folic acid-directed, hemoglobin-based PDT agents to treat cancer cells. Others have developed synthetic methodology for the preparation of different cross-linked hemoglobins. The synthetic work presents challenges including controlling reactions that may occur with the cross-linked hemoglobin, choosing the correct HPLC technique for analysis of the reaction products, and purifying and characterizing the X-linked hemoglobin-dye conjugates. The presentation will cover these topics and future work. |
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Bioorganic, Molecular Recognition, Asymmetric Reactions and Syntheses
11:00 AM-1:00 PM, Wednesday, September 10, 2003 Javits Convention Center -- Hall 1B/1C, Poster
Sci-Mix
Division of Organic Chemistry |