ORGN 576 |
Glutathione-mediated rescue of gold nanoparticle-inhibited beta-galactosidase
| Ayush Verma1, Joseph M. Simard2, and Vincent M. Rotello2. (1) Chemistry, University of Massachusetts-Amherst, 710 N. Pleasant St., Amherst, MA 01003, (2) Department of Chemistry, University of Massachusetts-Amherst, Amherst, MA 01003 |
The use of biocompatable systems to target protein surfaces at physiological concentrations and exploit cellular components for in vivo applications remains a challenge. In our study, we have used cationically functionalized gold nanoparticles to target beta-galactosidase. The enzyme is completely inhibited by these nanoparticles; inhibition is reversed via addition of glutathione, (the main thiol component of the cell), at physiological concentrations. This controlled release has potential applications in protein and drug delivery.  |
| |
|
Bioorganic, Molecular Recognition, Asymmetric Reactions and Syntheses
11:00 AM-1:00 PM, Wednesday, September 10, 2003 Javits Convention Center -- Hall 1B/1C, Poster
Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003
|