ORGN 449 |
New approach to the stereoselective synthesis of polyhydroxy compounds
| Hojae Choi, Bruno D. Chapsal, and Iwao Ojima. Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400 |
Developing new and efficient processes to synthesize polyhydroxy containing compounds are of great interest because this moiety is a key structural component of various powerful antibiotics and antifungal agents. A new approach to the stereoselective synthesis of polyhydroxy compounds has been studied, which includes the Rh-catalyzed intramolecular silylformylation of v-siloxyalkyne 1 as a key step. Subsequent diastereoselective hydrogenation, nucleophilic addition to aldehyde and the cleavage of Si-C bond by Tamao oxidation affords triol 3. |
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Physical Organic, Materials, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Tuesday, September 9, 2003 Hilton New York -- Americas Hall 1, Poster
Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003
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