Comparison of N-heterocyclic carbenes to phosphine ligands in Pd-catalyzed C-C bond formation of nucleosides

ORGN 453

John H. Hilmer and Mahesh K. Lakshman. Department of Chemistry, City College and the Graduate Center of the City University of New York, 138th Street at Convent Avenue, New York, NY 10031

N-Heterocyclic carbenes have found effective use in Pd-catalyzed C-C and C-N bond forming reactions among simpler systems. However, their applicability for similar transformations among the more complex systems such as nucleosides has not been evaluated to date. This study focuses on the comparison of imidazolium as well as dihydroimidazolium based complexes to phosphine based ones for Suzuki-Miyaura cross coupling.

 

Physical Organic, Materials, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Tuesday, September 9, 2003 Hilton New York -- Americas Hall 1, Poster

Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003