ORGN 221 |
| Jeffery T. Davis, Xiaodong Shi, Frank W. Kotch, Vladimir Sidorov, and James C. Fettinger. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 |
| We are using an approach for selective ion coordination that also enables formation of defined and functional assemblies. The method relies on self-assembly, where the ion serves as a template to bring together multiple organic ligands for its own encapsulation. The ligands, lipophilic nucleosides and related compounds, have self-complementary hydrogen bonding edges and extended aromatic surfaces that allow formation of both macrocyclic and tubular receptors. Our major goals are: 1) to understand structural, stereochemical and dynamic factors that control self-association and ion binding; 2) to tune kinetic stability to allow the regioselective modification of these assemblies; and 3) to design systems that selectively bind and transport cations, anions and ion pairs. |
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Supramolecular Chemistry and Molecular Recognition
8:30 AM-12:00 PM, Monday, September 8, 2003 Sheraton New York -- Imperial Ballroom B, Oral
Division of Organic Chemistry |