ORGN 529 |
Design and synthesis of artificial carbohydrates based on rigid polyproline scaffolds
| Deyun Wang, Ryan J. Casey, and Paramjit S. Arora. Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003 |
Among the three major classes of biopolymers (nucleic acids, proteins, and carbohydrates), the structure and function of carbohydrates remain the least understood. Carbohydrate-based compounds hold great promise as therapeutic agents and as tools in biology because of their role in cell-cell interactions, signaling, energy storage, etc. The conventional approaches to development of carbohydrate-mimetic libraries have met limited success primarily due to the challenges associated with carbohydrate synthesis. In this poster, we will outline a new approach to the development of artificial carbohydrates based on structured peptidic scaffolds. The distinctive feature of our approach is that it incorporates diversity-generating methods used in nature for the fabrication of biopolymers in contrast to methods used in generation of typical organic scaffolds. This method allows us to access a large set of novel carbohydrate structures even from a limited set of monomers. |
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Bioorganic, Molecular Recognition, Asymmetric Reactions and Syntheses
11:00 AM-1:00 PM, Wednesday, September 10, 2003 Javits Convention Center -- Hall 1B/1C, Poster
Sci-Mix
8:00 PM-10:00 PM, Monday, September 8, 2003 Javits Convention Center -- North Pavillion, Sci-Mix
Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003
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