ORGN 573 |
| Laura Baldini, Andrew J Wilson, Jason Hong, and Andrew Hamilton. Department of Chemistry, Yale University, 225 Prospect st, New Haven, CT 06520 |
| Arrays of sensors having different binding characteristics allow for the identification and classification of analytes by producing a composite response unique to each substrate. We synthesized a small combinatorial library of fluorophores capable of binding protein surfaces and formed a solution array of library members. Each fluorophore bears a combination of charged and hydrophobic groups on its periphery that modulates its affinity for the different protein surfaces, while binding is detected by the quenching of the receptor fluorescence. When incubated with proteins and irradiated with UV light the system permits the rapid visual detection and identification of a range of different proteins. |
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Bioorganic, Molecular Recognition, Asymmetric Reactions and Syntheses
11:00 AM-1:00 PM, Wednesday, September 10, 2003 Javits Convention Center -- Hall 1B/1C, Poster
Division of Organic Chemistry |