New Ru and Rh catalysts for asymmetric transfer hydrogenation

ORGN 596

Martin Wills1, Jérôme C. B. Hannedouche1, Aidan Hayes1, Aparecida M Kawamoto2, and David J Cross1. (1) Department of Chemistry, University of Warwick, Gibbet Hill road, Coventry, CV4 7AL, United Kingdom, (2) Chemistry Division, Space Aeronautical Institute, Aerospace Technical Center, Brazil, Pca Mal. Eduardo Gomes, 50, Vila das Acacias, Sao Jose dos Campos-SP, Brazil
We have prepared a number of new catalysts, typified by complexes 1 - 3 below, for the asymmetric transfer hydrogenation of ketones and imines which contain a 'tethering' group between chiral group and a face-co-ordinated ring. These complexes are highly stable and active in the reduction reactions, and may be prepared in gram quantities. The preparation and applications of the complexes will be described.

 

Bioorganic, Molecular Recognition, Asymmetric Reactions and Syntheses
11:00 AM-1:00 PM, Wednesday, September 10, 2003 Javits Convention Center -- Hall 1B/1C, Poster

Division of Organic Chemistry
The 226th ACS National Meeting, New York, NY, September 7-11, 2003