ORGNSunday, March 23, 2003

8:00 PM-10:00 PM Convention Center -- Hall G,Poster
Molecular Recognition, Combinatorial, Bioorganic
Organizer:L. McElwee-White
61Application of a flexible, asymmetric synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase
Jill M. McFadden, Susan M. Medghalchi, Jagan N. Thupari, Michael L. Pinn, Aravinda Vadlamudi, Katherine I. Miller, Francis P. Kuhajda, Craig A. Townsend
62Substrate specificity of b-lactam synthetase
Fumitaka Kudo, Craig A. Townsend
63Synthesis and diffusion measurements of flexible tetraether acyclic bisphosphocholines
Wilma Febo-Ayala, Scott A. Bradley, Aniruddha Patwardhan, David H. Thompson
64Synthesis of a thionated inhibitor for thimet oligopeptidase
Samantha J. Friedman, Julia H Miwa
65Synthesis of naturally occurring lipids and derivatives
Jin-Young Yoon, Jin-Seon Park, Mi-Geum Kim, Young-Ah Kim, So-Yeop Han
66Total synthesis of mauritine D, amphibine E, and their epimers
Young-Ah Kim, Hae-Jeong Min, So-Yeop Han
67A novel synthesis of peptidomimetics based on a pyridone scaffold: A versatile three-component reaction
Namal C Warshakoon, Rodney D. Bush
68Construction of a chemical library of unnatural polyketides by plant polyketide synthases
Ikuro Abe, Hiroyuki Morita, Yusuke Takahashi, Hiroshi Noguchi
69Synthesis of cyclic thiooligosaccharides: b-1,6-thio-linked cycloglucopyranosides
Linfeng Fan, Ole Hindsgaul
70Thermodynamics of reversibly formed encapsulation complexes
Elke C. Ullrich, Julius Rebek
71Triply interlocked 2-D self-assembly of modified triphenylenes
Carsten Siering, Roland Fröhlich, Siegfried R. Waldvogel
72Synthesis of D-leucine derived PNA monomers: DiSC2(5) aggregate formation on modified PNA/DNA templates
Rojendra Singh, Isil Dilek, Bruce Armitage
73Effect of template length on the formation of cyanine dye aggregates on PNA-DNA duplexes
Violeta L. Marin, Bruce Armitage
74Synthesis of new pyrene-containing, metal-chelating lipids and sensing of cupric ions
Bidhan C Roy, Binita Chandra, Daniel Hromas, Sanku Mallik
75Paper Withdrawn
76A new electron acceptor for supramolecular chemistry
Kathryn A. McMenimen, Joseph B. Carroll, Vincent M. Rotello, Thibaut Jarrosson, Darren G. Hamilton
77Surface-functionalized dendritic architectures
Pandi Bharathi, D Vutukuri, S Thayumanavan
78Water-soluble calix[4]arenes for molecular recognition and encapsulation
Suazette N. Reid, Suzanne B. Shuker
79Progress toward a synthesis of a half-chloptosin cyclohexapeptide
Jee-Youn Lee, Young-Ah Kim, So-Yeop Han
80Small catalytic peptides that operate an enamine mechanism: Improvement of catalytic activity and substrate specificity
Fujie Tanaka, Roberta Fuller, Carlos F. Barbas III
81Convergent evolution of aldolase antibodies in vitro: Correlation between catalytic activity and diketone binding within a set of aldolase antibodies
Fujie Tanaka, Roberta Fuller, Hyunbo Shim, Marikka Elia, Richard A. Lerner, Carlos F. Barbas III
82Polyhedral oligomeric silsequioxane-based supramolecular assemblies
Joseph B. Carroll, Vincent M. Rotello
83Porphyrin-appended anion receptors
Stephen D. Starnes, Sailaja Arungundram, Colene H. Saunders, Jeff C. Harper
84Sequence-selective enhancement of guanine alkylation by a minor groove binder
Sridhar Varadarajan, Barry Gold
85Sequence-specific DNA methylation in the minor groove
Sridhar Varadarajan, Dharini Shah, Prasad Dande, Samuel Settles, Barry Gold
86Molecular assembly of 1,2- and 1,3-bis(cyanomethyl)benzene with silver salts
Gerardo Marquez, Douglas M. Ho, Kathleen V. Kilway
87Molecular assembly of polycyanovinylarenes with silver salts
John R. VanScoy, Douglas M. Ho, Kathleen V. Kilway
88Molecular recognition of nucleic acids through SELEX
Joseph C. Manimala, Andrew D. Ellington, Eric V. Anslyn
89Origins of selectivity in noncovalent molecular imprinted polymers
Ryan L. Simon, Jason N. Campbell, David A. Spivak
90Synthesis and characterization of a novel L-serine-based cross-linking monomer for molecular imprinting
Martha Sibrian-Vazquez, David A. Spivak
91Influences on MIP selectivity by structural features close to the primary binding contacts
Jason N. Campbell, Ryan L. Simon, David A Spivak
92Guest-induced chirality in a self-assembled capsule
Alessandro Scarso, Julius Rebek, Alexander Shivanyuk, Osamu Hayashida
93Triply-threaded rotaxanes leading to molecular lifts
Jovica D. Badjic, J Fraser Stoddart
94Construction of a nanoscale molecular muscle based on molecular recognition
Ja-Young Han, J Fraser Stoddart
95Interlocked molecules beyond catenanes and rotaxanes: Investigating supramolecular assistance to covalent synthesis
Avril R. Williams, David J. Williams, Andrew J.P. White, J. Fraser Stoddart
96Investigating the potential of tris(2-pyridyl)methane derivatives as carbonic anhydrase mimics
Jiachang Gong, Bruce C. Gibb
97Synthesis and self-assembly of benzyl alcohols and benzyl alcohol deep-cavity cavitands
Jodie O. Green, Corinne L.D. Gibb, Bruce C. Gibb
98Synthesis and binding studies of three molecular baskets
Zachary R. Laughrey, Corinne L.D. Gibb, Tangi Senechal, Bruce C. Gibb
99Magic ring rotaxanes via olefin metathesis
Robert H. Grubbs, Stuart J. Cantrill, Andreas F. M. Kilbinger, Andrew W. Waltman, Erin N. Guidry
100Dimeric molecular capsule under redox control
Kwangyul Moon, Kaifer Angel
101Enzymological studies of carbon-bound fluorine in intermolecular interactions
Khanh C. Hoang, Oana Martin, Sandro Mecozzi
102Formation of a complex dimer assisted by water
Feihe Huang, Lev N. Zakharov, Arnold. L. Rheingold, Harry W. Gibson, Jason W. Jones
103Attachment of pyrene fluorophore to silica surfaces via the strongly hydrogen bonding 2-ureido-4-pyrimidone moiety
Loretta L. Crowe, Kyril M Solntsev, Laren Tolbert
104Conjugation of poor inhibitors of carbonic anhydrase with surface binding groups: A strategy to improve inhibitor efficiency
Bidhan C. Roy, Ryan Hegge, Theresa A. Rosendahl, Xiao Jia, Sanku Mallik
105Preparation of biphenyltetrazole-hydantoins and thiohydantoins as growth hormone secretagogues analogs
Rune Severinsen, Jesper Lau, Mikael Begtrup, Michael Ankersen
106Design of triplex-forming molecules
Jiansen Li, Yun-Hua Fan, Luis A. Marky, Barry Gold
107Diastereomeric discrimination: Resolution and development of a nonaromatic chiral acid resolving agent with arylamine efficacy
J. Luke Gatlin, Edward J. Valente
108A novel type of fluorescent boronic acid that shows large fluorescence intensity changes upon binding with a diol in aqueous solution at physiological pH
Binghe Wang, Wenqian Yang, Jun Yan, Greg Springsteen, Susan Deeter
109Calix-peptides: Modular strategy toward polyfunctional receptors and nanoscale assembles
Dmitry M. Rudkevich, Heng Xu
110A facile procedure for determining the pKa of weakly acidic pharmaceutical drugs and supramolecular ligands
Arno Kraft
111Dimethyl disulfide addition to 1,4-enynes: A new route to 2,5-dialkylthiophenes
Lizhi Zhu, Gordon V. Givan, Rachel A. Taylor, Robert E. Minto
112Isolation of a novel pacifigorgiane sesquiterpene
Larry G. French, Anthony J. Tracey, Carlos R. Ramirez-Sosa
113Synthesis of carbohydrate derivatives using clean chemistry
Rachel N. MacCoss, Paul E. Brennan, Steven V. Ley
114Total synthesis and antileukemic activity of the novel fatty acid 2-methoxy-14-methylpentadecanoic acid
Néstor M. Carballeira, Heidyleen Cruz, Elsie A. Orellano, Fernando A. González
115Briarellins J-P and polyanthellin A: New eunicellin-based diterpenes from the Caribbean gorgonian coral Briareum polyanthes
Claudia A. Ospina, Abimael D. Rodríguez
116Synthesis and bioactivity of erebusinone, a pigment from the antarctic sponge Isodictya erinacea
Young Chul Park, Bill J. Baker
117Design, synthesis, and evaluation of an enediyne with a new activation mechanism
Martin F Semmelhack, Lingyun Wu, Robert A. Pascal Jr., Douglas M. Ho
118Nonactin biosynthesis: Nonactin is cleaved by a serine esterase-like protein encoded by the nonactin resistance gene, nonR
James E. Cox, Nigel D. Priestley
119Photoreversible serine protease inhibitor synthesis and application
Junhai Yang, Ned A. Porter
120Photosensitive serine protease inhibitors based on the naphthalene ring system
Birgit Reeves, Ned A. Porter
121Synthesis of a new series of flavonoids
Michael E. McKendall, Tasha P. Smith, Maryam Foroozesh
122Chemical synthesis of a carbohydrate-based hydroxamic acid inhibitor of LpxCs
Xuechen Li, Taketo Uchiyama, Ole Hindsgaul
123Detection of dsDNA in homogeneous solution by hairpin polyamide-tetramethyl rhodamine conjugates
Victor C. Rucker, Alex R. Dunn, Shantanu Sharmu, H. B. Gray, Jay R. Winkler, Peter B. Dervan
124Synthesis of two analogs of 8-oxo-2'-deoxyguanosine, a potent promutagen
Michelle Hamm, Courtney Hoey, Waitman Aumann
125Systematic investigations of the effect of pH, urea, and neighboring amino acids on the random coil a-proton chemical shift of alanine in short peptides
Sonya L. McKay, Abby M. Maranda, Elizabeth A. Carlisle
126Synthesis and characterizations of some novel Horner-Wadsworth-Emmons reagents
Guifa Su, Ling Pan, Longmei Zeng
127Synthesis of an orthogonally protected triester platform related to marine cyclopeptides
Laurent Trembleau, Wook-Dong Cho, Byron W. Purse, Julius Rebek Jr.
128Design of novel fluorescence energy transfer cassettes utilizing a nucleobase as part of the donor
Guan-Sheng Jiao, Lars H. Thoresen, Kevin Burgess
129Novel synthesis and characterization of b-selenolo[2,3-b]pyrrolyl-L-alanine ([6,7]SeTrp) and its potential use in the elucidation of protein structure and dynamics
Duane M. Hatch, Louis A Silks III, Jeffrey O. Boles
130Efficient large-scale synthesis of picolinic acid derived Ni(II)complexes of glycine as new and synthetically efficient equivalents of nucleophilic glycine
Vadim A. Soloshonok, Hisanori Ueki, Trevor K. Ellis, Collin H. Martin
131Efficient method for removal of ruthenium by-products from olefin metathesis reactions
Jong Hyun Cho, B. Moon Kim
132Synthesis and structure of new acyclic analogs of nucleotides containing a 1,2- or 1,3-alkadienic skeleton
Valery K. Brel, Peter J Stang
133Synthesis of purine monomers for a-helical peptide nucleic acids
Philip Garner, Michelle M. Adams
134Design of heterocomplexes for supramolecular polymers and surface functionalization
Godefridus B.W.L. Ligthart, Rint P. Sijbesma, E.W. Meijer
135A geomorphic classification of antibody binding sites
K. N. Houk, Michelle Lee, Julie Schallhorn, Keiki Sugimoto, Andrew G. Leach
136A new strategy to induce g-turn: Peptides composed of alternating a-aminoxy acids and a-amino acids
Wei Li, Dan Yang
137Cross-linked hemoglobin dye conjugates for photodynamic therapy
Claudia M. Davila, David S. Crumrine, Kenneth Olsen
138b 2,2-Aminoxy acids: A new building block for turns and helices
Yu-Hui Zhang, Dan Yang, Nian-Yong Zhu
139Highly specific HPLC-UV method for the determination of cysteine and related aminothiols in biological samples
Venkataraman Amarnath, Kapil Amarnath, Holly L. Valentine, William M. Valentine, Kalyani Amarnath
140Quinomethionate acting as a photoinducible DNA cleaving agent
Jian Ying Qi, Albert S. C. Chan, Tianhu Li
141Synthesis and conductance study of trans-1,2-cyclopentane dicarboxamide linked gramicidin A dimers
David S. Crumrine, Shasikala Narayan, Courtney Williams, Samuel Cukierman
142Synthesis and application of polymer-supported (-)-sparteine as an external chiral ligand
Madugula S. R. Murty, John M. Rimoldi
143Synthesis of polymer-bound silyl azide for solid-phase organic synthesis
Richard T. Taylor, Matthew W. Bedore, Jennifer A. Fisher
144Tandem Petasis-Ugi multicomponent condensation reactions: A practical preparation of multidimensional libraries
Laura West, David E. Portlock, Ryszard Ostaszewski, Dinabandhu Naskar
145Reactivity and synthesis of substituted furanones and a novel approach to optically active derivatives applied in quorum-sensing inhibition bioassays
Tobias Persson, John Nielsen, Thomas Hjelmgaard
146Sonogashira chemistry for solid-phase organic synthesis
Judit Tulla-Puche, George Barany
147Suzuki cross-coupling using glass beads technology
Kokovi M. Lawson Daku, Jonathan M.J. Williams, Roger F. Newton
148Peptides as precursors to peptidomimetics: Novel approach to class B streptogramin antibiotics
Jennifer L. Robinson, Shelli R. McAlpine, Enrique V. Azevedo
149Catalytic asymmetric cylcopropanation using polymer-supported rhodium(II) catalysts
Sambasiva R. Poreddy, John M. Rimoldi
150High-throughput synthesis of anilide libraries on solid support
Moustafa E. El-Araby, Helen Guo, Richard S. Pottorf, Mark R. Player
151Novel antibiotics: Macrocyclic peptides designed to trap the Holliday junction
Lisa A. Liotta, Jason Smith, Shelli R. McAlpine
152A novel solid-phase synthesis of cyclic sulfonamide analogs of 4-hydroxyquinolinones
Caiding Xu, Ashok Bhandari, Christopher P. Holmes
153A solid-phase synthesis of diacylglycerol-lactones in macrokans as a prelude to the synthesis of protein kinase C isozyme-specific ligands by a combinatorial approach
Dehui Duan, Victor E. Marquez
154A facile parallel synthesis of indazoles with three-point diversities on solid support
Y. Sarah Dong, Jillian Basinger, Ashok Bhandari, Christopher P. Holmes
155A general solid-phase synthesis of 4-substituted quinolinones via a Pd-catalyzed negishi cross-coupling reaction
Caiding Xu, Lydie Yang, Ashok Bhandari, Christopher P. Holmes
156A novel method for mono-N-alkylation of primary amines and its application to synthesis of small organic compound libraries on the ACT solution-phase synthesizer, “The Solution”
Eugene Campian, HupChew Wong, Mahendra Menakuru, Justin Rogosky, Leslie Craddock, Jim Shannon, Hossain Saneii, Boliang Lou
157Combinatorial strategies for the synthesis of vancomycin derivatives with improved antibacterial properties
Aveline Yim, Martin Wills
158Solid-phase synthesis of a library of hydroxyproline derivatives
Anne L. Vergnon, Richard S. Pottorf, Mark R. Player
159Polymer-bound oxoammonium salt of TEMPO: A novel reagent for selective oxidation of alcohols
Sukanta Bhattacharyya, Lanchi Vo, Tejal Parekh, Jeff Labadie
160Utilization of 400–500-micron polystyrene beads for the preparation of encoded combinatorial libraries
Thuy X. H. Le, Huarong Ma, Tao Guo, Vinh Tran, Doug Hobbs, Peter Kieselback, Ed Heebner
161ACTU: A novel coupling agent for polymer-bound HOBt active esters
Tejal Parekh, Sukanta Bhattacharyya, Owen Gooding, Thomas J Lindberg, Jeff W. Labadie
162Removal of amines from solution: A comparison of solid-supported scavengers
A. J. Mendonca, Andrew F Coffey, John W Davies, Peter A Marsh, M. I. Richards, B. Thomas, D. J. Woodward, F.P. Warner
163High-throughput microwave-accelerated combinatorial synthesis: A plate-based approach
John J Lord, Christopher R. Sarko
164Solid-phase synthesis of di- and trisubstituted N-acyl ureas: A novel approach
Jacob Ravn, Jesper Lau, Mikael Begtrup, Michael Ankersen
165Highly regioselective parallel solid-phase synthesis of new tetracyclic 1,3,5-triazino[1,2-a]benzimidazoles
Cornelia E. Hoesl, Adel Nefzi, Richard A. Houghten
166Lead-generation libraries based on a 1,2,5-thiadiazole-1-oxide template
Richard D. Gless Jr., Maureen M. McKenna, Michael T. Keller, Stephen C. Smith, Christopher Mathews
167Lead-generation libraries based on a 3-amino-1,4-oxo-1,2,5-thiadiazole acetamide template
Richard D. Gless Jr., Maureen M. McKenna, Michael T. Keller, Stephen C. Smith
168New technique to parallel solution-phase synthesis of esters by solid-supported sulfonyl chloride cartridge
Shahnaz Ghassemi, Peter Rahn, Michael Webb
169Synthesis of an isoxazolinopyrrole library
Sung Hee Hwang, Mark J. Kurth

Symposium Grid -- Division of Organic Chemistry -- Session Listing

The 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003