Step economy, the ideal synthesis, and new metal-catalyzed reactions

ORGN 37

Paul A. Wender, Department of Chemistry, Department of Chemistry, Stanford University, Stanford, CA 94305-5080
Studies in our laboratory focus on problems in chemistry (new reactions), biology (novel modes of action), and medicine (new therapeutic leads and drug delivery systems). These interconnected activities are enabled and driven by an interest in the synthesis of novel structures with novel modes of action and clinical potential. This lecture will focus of this synergy between synthesis and medicine that has led to a variety of new transition metal catalyzed reactions (e.g., [4+4], [4+2], [5+2], hetero [5+2], [6+2], three component and four component cycloadditions) and their use in complex molecule synthesis, the assembly of novel scaffolds for chemical libraries, and the practical synthesis of synthetic building blocks .