ORGN 230 |
| C-H. Wong, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 |
| As new advances in functional genomics and proteomics research continue to emerge, the roles of carbohydrates in biological recognition and protein glycosylation have become a subject of current interest. This lecture will present our recent work on development of chemo-enzymatic synthesis of oligosaccharides and glycoproteins and on the design and synthesis of inhibitors targeting carbohydrate enzymes and specific RNA sequences associated with bacterial infection, inflammatory reactions and cancer metastasis. Koeller, K.M.; Wong, C.-H. “Enzymes for chemical synthesis” Nature (2001) 409, 232. Ritter, T.K.; Wong, C.-H. “Carbohydrate-based antibiotics: A new approach to tackle the problem of antibiotic resistance” Angew. Chem. Int. Ed. (2002) 40, 3508. Sucheck, S.J.; Wong, A.L.; Koeller, K.M.; Boehr, D.D.; Draker, K.; Sears, P.; Wright, G.D.; Wong, C.-H. “Design of bifunctional antibiotics that target bacterial RNA and inhibit resistance causing enzymes” J. Am. Chem. Soc. (2000) 122, 5230. Zhang, Z.; Ollmann, I.R.; Ye, X.-S; Wischnat, R.; Baasov, T.; Wong, C.-H. “Programmable one-pot oligosaccharide synthesis” J. Am. Chem. Soc. (1999) 121, 734. |
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Alfred Bader Award in Bioinorganic or Bioorganic Chemistry
1:45 PM-5:00 PM, Monday, March 24, 2003 Convention Center -- La Nouvelle Ballroom A/B, Oral
Division of Organic Chemistry |