ORGN 2 |
| Jeffrey S. Johnson, Department of Chemistry, Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290 |
| This talk will focus on our studies directed toward the development of new catalyzed tandem reactions. Particular transformations of interest include reactions between acylsilanes and cyanide salts that generate, via cyanation and [1,2]-Brook rearrangement, siloxy nitrile enolates that can be trapped in a number of productive bond constructions. A new domino cyanation/Brook rearrangement/C-acylation reaction for the preparation of highly functionalized unsymmetrical malonic acid derivatives from acylsilanes and cyanoformate esters will be described. Progress on the development of an enantioselective variant, as well as an extension to a new catalytic, regiospecific cross silyl benzoin reaction will be detailed. |
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James Flack Norris Award in Physical Organic Chemistry
8:35 AM-12:00 PM, Sunday, March 23, 2003 Convention Center -- La Nouvelle Ballroom A/B, Oral
Division of Organic Chemistry |